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ABSTRACT Follow-up observations of neutrino events have been a promising method for identifying sources of very-high-energy cosmic rays. Neutrinos are unambiguous tracers of hadronic interactions and cosmic rays. On 2020 June 15, IceCube detected a neutrino event with an 82.8 per cent probability of being astrophysical in origin. To identify the astrophysical source of the neutrino, we used X-ray tiling observations to identify potential counterpart sources. We performed additional multiwavelength follow-up with NuSTAR and the VLA in order to construct a broadband spectral energy distribution (SED) of the most likely counterpart. From the SED, we calculate an estimate for the neutrinos we expect to detect from the source. While the source does not have a high predicted neutrino flux, it is still a plausible neutrino emitter. It is important to note that the other bright X-ray candidate sources consistent with the neutrino event are also radio-quiet active galactic nuclei. A statistical analysis shows that 1RXS J093117.6+033146 is the most likely counterpart (87.5 per cent) if the neutrino is cosmic in origin and if it is among X-ray detectable sources. This result adds to previous results suggesting a connection between radio-quiet AGN and IceCube neutrino events. 

Abstract Electrical synapses formed by Connexin 36 (Cx36) serve as a fast means for communication in the nervous systems. Only little is known about the protein complexes that constitute these synapses. In the present study, we applied different BioID strategies to screen the interactomes of Connexin 36 the major neuronal connexin and its zebrafish orthologue Cx35b in retinal neurons. Forin vivoproximity labeling in mice, we took advantage of the Cx36-EGFP strain and expressed a GFP-nanobody-TurboID fusion construct selectively in AII amacrine cells. Forin vivoBioID in zebrafish, we generated a transgenic line expressing a Cx35b-TurboID fusion under control of the Cx35b promoter. Both strategies allowed us to capture a plethora of molecules that were associated with electrical synapses and showed a high degree of evolutionary conservation in the proteomes of both species. Besides known interactors of Cx36 such as ZO-1 and ZO-2 we have identified more than 50 new proteins, such as scaffold proteins, adhesion molecules and regulators of the cytoskeleton. We further determined the subcellular localization of these proteins in AII amacrine and tested potential binding interactions with Cx36. Of note, we identified signal induced proliferation associated 1 like 3 (SIPA1L3), a protein that has been implicated in cell junction formation and cell polarity as a new scaffold of electrical synapses. Interestingly, SIPA1L3 was able to interact with ZO-1, ZO-2 and Cx36, suggesting a pivotal role in electrical synapse function. In summary, our study provides a first detailed view of the electrical synapse proteome in retinal neurons. 

Abstract Understanding the evolution of massive binary stars requires accurate estimates of their masses. This understanding is critically important because massive star evolution can potentially lead to gravitational-wave sources such as binary black holes or neutron stars. For Wolf–Rayet (WR) stars with optically thick stellar winds, their masses can only be determined with accurate inclination angle estimates from binary systems which have spectroscopic M sin i measurements. Orbitally phased polarization signals can encode the inclination angle of binary systems, where the WR winds act as scattering regions. We investigated four Wolf–Rayet + O star binary systems, WR 42, WR 79, WR 127, and WR 153, with publicly available phased polarization data to estimate their masses. To avoid the biases present in analytic models of polarization while retaining computational expediency, we used a Monte Carlo radiative-transfer model accurately emulated by a neural network. We used the emulated model to investigate the posterior distribution of the parameters of our four systems. Our mass estimates calculated from the estimated inclination angles put strong constraints on existing mass estimates for three of the systems, and disagree with the existing mass estimates for WR 153. We recommend a concerted effort to obtain polarization observations that can be used to estimate the masses of WR binary systems and increase our understanding of their evolutionary paths. 

ABSTRACT The progenitor systems and explosion mechanism of Type Ia supernovae are still unknown. Currently favoured progenitors include double-degenerate systems consisting of two carbon-oxygen white dwarfs with thin helium shells. In the double-detonation scenario, violent accretion leads to a helium detonation on the more massive primary white dwarf that turns into a carbon detonation in its core and explodes it. We investigate the fate of the secondary white dwarf, focusing on changes of the ejecta and observables of the explosion if the secondary explodes as well rather than survives. We simulate a binary system of a $$1.05\, \mathrm{M_\odot }$$ and a $$0.7\, \mathrm{M_\odot }$$ carbon-oxygen white dwarf with $$0.03\, \mathrm{M_\odot }$$ helium shells each. We follow the system self-consistently from inspiral to ignition, through the explosion, to synthetic observables. We confirm that the primary white dwarf explodes self-consistently. The helium detonation around the secondary white dwarf, however, fails to ignite a carbon detonation. We restart the simulation igniting the carbon detonation in the secondary white dwarf by hand and compare the ejecta and observables of both explosions. We find that the outer ejecta at $$v~\gt ~15\, 000$$ km s−1 are indistinguishable. Light curves and spectra are very similar until $$\sim ~40 \ \mathrm{d}$$ after explosion and the ejecta are much more spherical than violent merger models. The inner ejecta differ significantly slowing down the decline rate of the bolometric light curve after maximum of the model with a secondary explosion by ∼20 per cent. We expect future synthetic 3D nebular spectra to confirm or rule out either model. 

Abstract Nebular-phase observations of peculiar Type Ia supernovae (SNe Ia) provide important constraints on progenitor scenarios and explosion dynamics for both these rare SNe and the more common, cosmologically useful SNe Ia. We present observations from an extensive ground- and space-based follow-up campaign to characterize SN 2022pul, a super-Chandrasekhar mass SN Ia (alternatively “03fg-like” SN), from before peak brightness to well into the nebular phase across optical to mid-infrared (MIR) wavelengths. The early rise of the light curve is atypical, exhibiting two distinct components, consistent with SN Ia ejecta interacting with dense carbon–oxygen (C/O)-rich circumstellar material (CSM). In the optical, SN 2022pul is most similar to SN 2012dn, having a low estimated peak luminosity (M_B= −18.9 mag) and high photospheric velocity relative to other 03fg-like SNe. In the nebular phase, SN 2022pul adds to the increasing diversity of the 03fg-like subclass. From 168 to 336 days after peakB-band brightness, SN 2022pul exhibits asymmetric and narrow emission from [Oi]λλ6300, 6364 (FWHM ≈ 2000 km s⁻¹), strong, broad emission from [Caii]λλ7291, 7323 (FWHM ≈ 7300 km s⁻¹), and a rapid Feiiito Feiiionization change. Finally, we present the first ever optical-to-MIR nebular spectrum of an 03fg-like SN Ia using data from JWST. In the MIR, strong lines of neon and argon, weak emission from stable nickel, and strong thermal dust emission (withT≈ 500 K), combined with prominent [Oi] in the optical, suggest that SN 2022pul was produced by a white dwarf merger within C/O-rich CSM. 

Abstract We present JWST near-infrared (NIR) and mid-infrared (MIR) spectroscopic observations of the nearby normal Type Ia supernova (SN) SN 2021aefx in the nebular phase at +255 days past maximum light. Our Near Infrared Spectrograph (NIRSpec) and Mid Infrared Instrument observations, combined with ground-based optical data from the South African Large Telescope, constitute the first complete optical+NIR+MIR nebular SN Ia spectrum covering 0.3–14μm. This spectrum unveils the previously unobserved 2.5−5μm region, revealing strong nebular iron and stable nickel emission, indicative of high-density burning that can constrain the progenitor mass. The data show a significant improvement in sensitivity and resolution compared to previous Spitzer MIR data. We identify numerous NIR and MIR nebular emission lines from iron-group elements as well as lines from the intermediate-mass element argon. The argon lines extend to higher velocities than the iron-group elements, suggesting stratified ejecta that are a hallmark of delayed-detonation or double-detonation SN Ia models. We present fits to simple geometric line profiles to features beyond 1.2μm and find that most lines are consistent with Gaussian or spherical emission distributions, while the [Ariii] 8.99μm line has a distinctively flat-topped profile indicating a thick spherical shell of emission. Using our line profile fits, we investigate the emissivity structure of SN 2021aefx and measure kinematic properties. Continued observations of SN 2021aefx and other SNe Ia with JWST will be transformative to the study of SN Ia composition, ionization structure, density, and temperature, and will provide important constraints on SN Ia progenitor and explosion models.